Clinical Investigation

Efects of liver diseases on pregnancy and perinatal results: Comparison of 161 pregnant women with liver disease TO 180 healty pregnant

  • Ahmet Mete Ergenoglu
  • Ahmet Özgür Yeniel
  • Cem Yasar Sanhal
  • Mert Kazandi

Turk J Obstet Gynecol 2010;7(4):273-278

Objective: To determine the demographic properties, clinical features, laboratory findings and perinatal results of the patients who had liver diseases during their pregnancies. Material and Methods: We retrospectively evaluated the medical records of 12241 pregnant women who had been treated in our clinic between January 2004 and July 2009. 161 of them (study group) had liver disease. For the control group, 180 patients,who did not have any problems on their routine controls, were chosen. Age, gravida, parity, gestational week, amnion fluid levels, birth week-weight-route, APGAR values of the first and fifth minutes, ALT, AST, ALP, GGT, Total protein, albumin, globulin, total-direct-indirect bilirubin, INR, APTT, leucocyte, heamoglobuline, heamotocryte, platelets, blood urea, creatinine and sodium values were examined. Results: Demographic and clinical variables did not differ between groups. There was statistically significant difference in ALT, AST, ALP, GGT, total protein, albumin, total-direct-indirect billurubin, leucocyte, INR and creatinine values. We divided the study group in to 4 sub-groups; hepatitis B porters, cholestasis, asymptomatic liver function test abnormalities and others. We did not find any differences between groups in all parameters. Conclusion: The obstetrical complications of liver diseases in pregnancies may sometimes cause severe damages. With appropriate management and treatmant modalities, satisfying perinatal results could be gained.

Keywords: Liver Disease, Pregnancy, Perinatal results