Clinical Investigation

Comparison of mean platelet volume and serum bile acid levels in intrahepatic cholestasis of pregnancy


  • Nilgün Güdücü
  • Başak Özge Kayan
  • Herman Işçi
  • Kılıç Aydınlı
  • Alin Başgül Yiğiter
  • İlkkan Dünder

Turk J Obstet Gynecol 2013;10(4):236-241


The aim of this study was to investigate the relationship between serum bile acid levels (SBA) and mean platelet volume (MPV), a proinflammatory marker and to detect the role of MPV as a marker of fetal well-being in patients with intrahepatic cholestasis of pregnancy (ICP).


We compared the biochemical parameters of pregnants with ICP and the control group retrospectively.


Pregnants with ICP had statistically significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fasting SBA levels and the gestational week at delivery was higher in the control group (p < 0.05). There was no statistically significant relationship between MPV and hemoglobin, hematocrite, white blood cell count and thrombocyte levels of the groups ( p > 0.05). Mean gestational week at delivery was statistically significantly lower in pregnants with ICP when compared to the control group (37.95 ± 0.92 weeks and 37.25 ± 1.25 weeks, p < 0.05 respectively).


There was no relationship between MPV and biochemical parameters used to define ICP. But the rate of preterm delivery increased as SBA levels increased.

Keywords: serum bile acid levels, mean platelet volume, pregnancy