Clinical Investigation

Effects of Estrogen Replacement Therapy to the Renal Function in Postmenopausal Women


  • Setenay Arzu Yılmaz

Turk J Obstet Gynecol 2011;8(4):249-258


To asses the effect of estrogen replacement therapy to the renal functions in postmenopausal women following the surgery.


This is prospestive randomised cross-sectional descriptive study.


Gazi University School Of Medicine Obstetrics and Gynecology Department between October 2000 through July 2001


Fifty-eight patients who had been undergone total abdominal hysterectomy and bilateral salpingo-oopherectomy due to benign gynecologic disorders were enrolled in this present study.


Breast and pelvic examination had been before operation. Cervical smear, blood glucose, lipid profile, liver and renal functional tests, complete blood count and urine analysis revelaed. Mammography and pelvic ultrasonography applied to all patients.

Main outcome measures:

Body mass index (BMI) has been measured with patient’s weight (kg) and heights by the formula ‘weight(kg) /height (m2). Obese patients defined as boy mass index over 30. The patients who can use ERT randomised as two groups. Group I received transdermal estrogen (Climara TTS) or oral conjugated estrogen (Premarin 0,625 mg), group II did not. Microalbuminuria, creatinine clearance in 24 hour urine specimen were compared preoperatively and postoperative 1st and 6 th months respectively.


At the end of six month of observation in the group who were in surgical menopause and given ERT, statistically significant decline in microalbuminuria was observed. However, in the group who were in surgically menopause and did not receive ERT, level of microalbuminuria did not change significantly. In the group who were oopherectomised following naturel menopause, microalbuminuria level changed clinically after ERT but was not stastistically significant. Whereas in the group who were not given ERT, decline in the level of microalbuminuria was seen and this finding is stastistically significant (p<0,05).


We concluded that ERT is protective on renovasculer system.

Keywords: postmenopause, microalbuminurea, estrogen